Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis
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چکیده
منابع مشابه
Muscarinic Acetylcholine Receptor Regulates Phosphatidylcholine Phospholipase
The hydrolytic activity of phosphatidylcholine phospholipase D in the synaptosomes from canine brain was examined using a radiochemical assay with 1,Z-dipalmitoyl-sn-glycerol-3-phosphoryl[3H]choline as the exogenous substrate. The involvement of G protein(s) in regulation of this enzyme was demonstrated by a 2to %fold stimulation of the basal activity (4.81 2 0.44 nmol choline released/mg prote...
متن کاملSignal-dependent activation of phosphatidylcholine hydrolysis: role of phospholipase D.
29. Brooks, G., Evans, A. T., Aitken, A. & Evans, F. J. (1987) Cancer Lett. 38,165-170 Evans, A. T., Brooks, G. & Evans, F. J. (1990) Cancer Lett. 49,2529 Evans, F. J., Kinghorn, A. D. & Schmidt, R. J. (1975) Acta Pharmacol. Toxicol. 37,250-256 Tapley, P. M. & Murray, A. W. (1985) Eur. J. Biochem. 151,419-423 Edwards, M. C., Williamson, E. M., Formakong, E., Brooks, G. & Evans, F. J. (1987) Bio...
متن کاملMechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues
The role of a guanine nucleotide-binding protein (Gk) in the coupling between muscarinic receptor activation and opening of an inwardly rectifying K+ channel [IK(M)] was examined in cardiac atrial myocytes, using hydrolysis-resistant GTP analogues. In the absence of muscarinic agonist, GTP analogues produced a membrane current characteristic of IK(M). The initial rate of appearance of this rece...
متن کاملPhospholipase C-mediated hydrolysis of phosphatidylcholine is activated by muscarinic agonists.
The phospholipase C-catalysed breakdown of inositol-containing phospholipids is an important source of diacylglycerol in cells stimulated by several agonists. However, recent experimental evidence suggests that major phospholipids such as phosphatidylcholine may also be substrates of the phosphodiesteratic hydrolysis activated by hormones, growth factors and oncogene products. We show here that...
متن کاملMuscarinic Receptor - Mediated Phosphoinositide Hydrolysis in Rat Brain
Objective: Activation of cholinergic muscarinic receptors leads to activation of membrane bound phospholipase C, leading to generation of IP3 and diacylglycérol, The present study aimed at measuring muscarinic receptor-mediated phosphoinositide breakdown in three different regions of rat brain. Methods: Cortical, hippocampal and striatal slices labeled with [3H] myo-inositol were incubated with...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)63762-7